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When New Orleans paramedics and longtime best friends Steve and Dennis are called to a series of bizarre, gruesome accidents, they chalk it up to the mysterious new party drug found at the scene. But after Dennis’s oldest daughter suddenly disappears, Steve stumbles upon a terrifying truth about the supposed psychedelic that will challenge everything he knows about reality—and the flow of time itself.

Starring Anthony Mackie, Jamie Dornan, Katie Aselton and Ally IIoannides, the film is released October 23 in U.S. cinemas and drive-ins, with the UK date to be announced.